Effect of chronic administration of ostruthin on depression-like behavior in chronically stressed mice

Effect of chronic administration of ostruthin on depression-like behavior in chronically stressed mice

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We have previously shown that a single dose of a TREK-1 channel activator, ostruthin, exhibited antidepressant and anxiolytic effects in acute behavioral test models in mice.To assess the potential clinical application, it is essential to grandpas best evaluate the effects of long-term administration of ostruthin in a chronically stressed mouse model, which is considered to be similar to the clinical condition of major depression in humans.Here, we tested the effects of a single and a 7-day administration of ostruthin on mice that were subjected to chronic unpredictable mild stress (CUMS).

A single administration of ostruthin click here showed antidepressive effects in the tail suspension and forced swim tests of CUMS-treated mice.Unexpectedly, the 7-day administration exhibited only insignificant antidepressive and anxiolytic effects.The 7-day regimen did not affect food intake or body-weight gain, suggesting the absence of apparent cytotoxicity.

The mice receiving the 7-day administration had significantly lower blood concentrations of ostruthin compared to those receiving a single dose, suggesting an upregulation of drug-metabolizing activities.These findings suggest that there is a need for stable TREK-1 channel activators that are not affected by drug metabolism.